Exposure to 'Forever Chemicals' PFAS May Accelerate Biological Aging in Men
A recent study reveals that exposure to perfluoroalkyl and polyfluoroalkyl substances, known as PFAS or ‘forever chemicals’, is strongly suspected of accelerating the biological aging process in men aged 50 to early 60.
These substances are dubbed ‘forever chemicals’ because they take years to break down in both the environment and the human body. According to data from the National Academies of Sciences, Engineering, and Medicine, these substances are found in the blood of approximately 98% of the US population.
The study, published in the journal Frontiers in Aging, highlights the acceleration of epigenetic aging, which measures a person’s biological age compared to their chronological age. The results show that the most significant impact is found in men.
‘The association between PFAS exposure and accelerated epigenetic aging is most pronounced in men aged 50-65,’ said Xiangwei Li, a professor of epidemiology at the Shanghai Jiao Tong University School of Medicine, via email.
Li added that in younger or older men, the association tends to be weaker. While women also showed an association, it was smaller and less consistent compared to middle-aged men.
Experts speculate that there may be gender-specific effects because PFAS are endocrine disruptors that regulate metabolism, growth, and reproduction. In men, PFAS accumulation may lower testosterone levels, impair sperm quality, and increase the risk of testicular and kidney cancer.
Jane Muncke, chief scientific officer at the Food Packaging Forum, explained that women tend to eliminate certain PFAS more quickly through biological processes such as menstruation, pregnancy, and breastfeeding. This difference in accumulation between men and women usually only narrows after menopause.
Used since the 1950s to make consumer products resistant to water, oil, and heat (such as non-stick cookware), PFAS have long been linked to various serious health problems, including cancer, hormone disruption, high cholesterol, and liver damage.
Although the chemical industry continues to create new PFAS variants that have not been extensively studied, this study found that less popular types such as PFNA and PFOSA still have a strong association with accelerated biological aging in men.
Given the widespread presence of PFAS, completely avoiding them is considered unrealistic. However, Xiangwei Li suggests practical steps to reduce risk.
‘However, it is important not to panic. Our study shows an association, not proof of causation,’ said Li. ‘However, reducing exposure where possible, such as using certified water filters, following local water advisories, and minimizing contact with stain- or oil-resistant materials, may be a reasonable step.’ (CNN/Z-2)
Researchers have successfully developed a photocatalytic method to break down harmful PFAS chemicals using sunlight.