Weight Management Key to Preventing Fatty Liver Disease MASLD

Medical experts have stated that weight management in obese patients is a crucial treatment approach to prevent the metabolic disorder of fatty liver disease, known as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Early detection and comprehensive management are necessary to avert the risk of severe complications such as cirrhosis and liver cancer.

Internal medicine specialist and consultant in gastroenterology and hepatology from Cipto Mangunkusumo Hospital, Rino Alvani Gani, explained that individuals with obesity, type 2 diabetes, and impaired liver function must be vigilant about this disease spectrum. According to him, MASLD begins with fat accumulation which, if not managed, can develop into Metabolic Dysfunction-Associated Steatohepatitis (MASH).

“If the risk factors are not managed properly, some patients may experience progression to MASH, a more severe form involving inflammation and liver cell damage,” said Prof. Rino in an official statement in Jakarta, Friday (12/6/2026).

He further stressed that MASLD is closely linked to broader cardiometabolic risks, as cardiovascular disease is the leading cause of death in patients with fatty liver conditions.

In agreement, endocrinology expert Dicky Levenus Tahapary affirmed that obesity is a complex chronic medical condition. He stated that the primary goal of obesity management is not merely reducing the number on the scale, but achieving quality weight loss and long-term metabolic health.

“Excess body fat, especially visceral fat, can trigger insulin resistance and inflammation that impacts the liver, heart, and blood vessels,” explained Dr. Dicky. He also added that the use of pharmacological therapy, including GLP-1 RA-based innovations, can be considered based on the patient’s clinical condition.

In the momentum of Global Fatty Liver Day 2026, the Indonesian Ministry of Health together with Novo Nordisk Indonesia continues to promote education and early detection. The Director of Non-Communicable Diseases at the Indonesian Ministry of Health, Siti Nadia Tarmizi, reminded that obesity is the “mother of all chronic diseases”.

“As the prevalence of obesity increases in Indonesia, the risk of developing fatty liver also rises. We urge the public to be more vigilant and undergo early detection to maintain liver health,” concluded Nadia.