Depok (ANTARA) - Dr Nurhayati, a doctoral researcher at the\nUniversity of Indonesia\u2019s Faculty of Engineering (FTUI), has produced a\nbiomaterial innovation based on Indonesia\u2019s marine resources by\ndeveloping a wound dressing hydrogel based on cellulose nanofibre (CNF)\nfrom Sargassum seaweed, which has the potential to be a candidate\nmaterial for chronic wound dressings.<\/p>\n
\u201cSargassum seaweed, which has not been widely utilised until now, is\nprocessed into CNF with an average diameter of 9.50 nanometres,\u201d\nNurhayati stated in her report on Saturday.<\/p>\n
She explained that this CNF material was then formulated with\npolyvinyl alcohol (PVA), sodium alginate, and chitosan using the\nfreeze-thaw method. The resulting multi-component hydrogel, with an\noptimal composition (5 per cent PVA, 2 per cent sodium alginate, 1 per\ncent chitosan, and 0.25 per cent CNF), demonstrated superior performance\ncompared to commercial materials, featuring a swelling ratio of 156.97\nper cent, a gel content of 95.81 per cent, a tensile strength of 0.48\nMPa, an elongation of 371.43 per cent, and a degradation rate of 8.39\nper cent within three days.<\/p>\n
In addition to physical and mechanical aspects, this research also\nevaluated the biological aspects of the hydrogel. Cytotoxicity tests\nshowed cell viability above 70 per cent, in accordance with ISO 10993-5\nstandards, while scratch assay tests showed a wound gap closure of 63.73\nper cent within 24 hours, which was higher than the control group.<\/p>\n
\u201cThese findings confirm the potential of Sargassum CNF as a hydrogel\nreinforcement for clinical applications, particularly for chronic wounds\nsuch as diabetic foot ulcers,\u201d she said.<\/p>\n
The research developed also opens opportunities for the development\nof Sargassum as a raw material for renewable biomaterials.<\/p>\n
The processing of local marine biomass into CNF and subsequently into\nhydrogel material demonstrates how biological resources that have not\nbeen optimally utilised can be processed through a material technology\napproach to produce products with higher added value.<\/p>\n
Nurhayati, who is also a researcher at the BRIN Centre for Biomass\nand Bioproduct Research, successfully achieved a perfect GPA of 4.00\nwith cum laude distinction after successfully defending her dissertation\ntitled \u201cFabrication of Renewable Hydrogel Reinforcement Based on\nSargassum Cellulose Nanofibre as a Wound Dressing Candidate\u201d.<\/p>", "url": "https:\/\/jawawa.id\/newsitem\/ftui-develops-wound-dressing-hydrogel-from-sargassum-seaweed-1788602557", "image": "" }, "sponsor": "Okusi Associates", "sponsor_url": "https:\/\/okusiassociates.com" }